diff --git a/.github/scripts/strategy-matrix/generate.py b/.github/scripts/strategy-matrix/generate.py
index 8284a1ee96..7a2e0b459d 100755
--- a/.github/scripts/strategy-matrix/generate.py
+++ b/.github/scripts/strategy-matrix/generate.py
@@ -256,6 +256,8 @@ def generate_strategy_matrix(all: bool, config: Config) -> list:
                 }
             )
             # Add TSAN + UBSAN configuration.
+            # TSAN instrumentation significantly increases memory usage during
+            # compilation, so reduce build parallelism to avoid OOM on CI runners.
             configurations.append(
                 {
                     "config_name": config_name + "-tsan-ubsan",
@@ -266,6 +268,7 @@ def generate_strategy_matrix(all: bool, config: Config) -> list:
                     "os": os,
                     "architecture": architecture,
                     "sanitizers": "thread,undefinedbehavior",
+                    "nproc_subtract": 20,
                 }
             )
         else:
@@ -282,6 +285,20 @@ def generate_strategy_matrix(all: bool, config: Config) -> list:
                 }
             )
 
+    # TEMPORARY: Only build previously-failing sanitizer variants to save CI.
+    # Remove this filter once these configs pass.
+    sanitizer_only = [
+        c
+        for c in configurations
+        if c["sanitizers"]
+        and (
+            ("gcc-13" in c["config_name"] and "asan" in c["config_name"])
+            or ("clang-20" in c["config_name"] and "tsan" in c["config_name"])
+        )
+    ]
+    if sanitizer_only:
+        return sanitizer_only
+
     return configurations
 
 
diff --git a/.github/workflows/reusable-build-test.yml b/.github/workflows/reusable-build-test.yml
index 0086cbbfb5..2dddd0cee4 100644
--- a/.github/workflows/reusable-build-test.yml
+++ b/.github/workflows/reusable-build-test.yml
@@ -58,5 +58,6 @@ jobs:
       image: ${{ contains(matrix.architecture.platform, 'linux') && format('ghcr.io/xrplf/ci/{0}-{1}:{2}-{3}-sha-{4}', matrix.os.distro_name, matrix.os.distro_version, matrix.os.compiler_name, matrix.os.compiler_version, matrix.os.image_sha) || '' }}
       config_name: ${{ matrix.config_name }}
       sanitizers: ${{ matrix.sanitizers }}
+      nproc_subtract: ${{ matrix.nproc_subtract && matrix.nproc_subtract || 2 }}
     secrets:
       CODECOV_TOKEN: ${{ secrets.CODECOV_TOKEN }}
diff --git a/conan/profiles/sanitizers b/conan/profiles/sanitizers
index 7fb59a8250..85827558b0 100644
--- a/conan/profiles/sanitizers
+++ b/conan/profiles/sanitizers
@@ -13,7 +13,7 @@ include(default)
 
             {% if "address" in sanitizers %}
                 {% set _ = sanitizer_list.append("address") %}
-                {% set model_code = "-mcmodel=large" %}
+                {% set model_code = "-mcmodel=medium" %}
                 {% set _ = defines.append("BOOST_USE_ASAN")%}
                 {% set _ = defines.append("BOOST_USE_UCONTEXT")%}
             {% elif "thread" in sanitizers %}